TREM2 ameliorates anesthesia and surgery-induced cognitive impairment by regulating mitophagy and NLRP3 inflammasome in aged C57/BL6 mice
- Resource Type
- ACADEMIC JOURNAL
- Jiang, Wenwen a, 1; Liu, Fang b, 1; Li, Hongqing a; Wang, Kexin a; Cao, Xuezhao a, ⁎; Xu, Xiaohan a; Zhou, Yongjian a; Zou, Jie a; Zhang, Xinyue a; Cui, Xiaotong a
- In Neurotoxicology May 2022 90:216-227
@@@@Highlights •TREM2 improved postoperative cognitive impairment by inhibiting neuro-inflammation.•Anesthesia and surgery induced mitophagy dysfunction, which was restored by TREM2.•TREM2 inhibited NLRP3 inflammasome activation via reversing mitophagy function.•TREM2 overexpression reversed the reduction of PSD-95 and BDNF following surgery.