Many lepidopterans are among the diverse arthropod pests that attack tomato crop. Some of these lepidopterans are more problematic and widespread than others. This chapter concerns nine of the particularly problematic lepidopterans on tomatoes. Because of their assorted bionomics, some species are more damaging in certain regions. These lepidopterans attack tomato foliage, stems, immature and ripe fruits, and they all have hosts other than tomato. As with other tomato pests, several approaches are available to manage these pests, including plant resistance, biological control, sanitation, trapping, mating disruption, use of scouting and thresholds before making insecticide treatments, and selection of narrow spectrum insecticides that minimally impact natural enemies. Growers are advised to use an integrative approach that utilizes as many of these strategies as possible.