This is an observational study on 102 women aged 25-45 years to evaluate if the E2V/DNG pill has any impact on quality of life (QoL) and sexual function (FSF). Thirty-nine women were younger than 35 years (group A), and 63 women were 35 years old or older (group B). At baseline and after 6 months, patients received the Italian validated version of the Short Form-36 questionnaire and the Italian validated version of the Female Sexual Function Index questionnaire. Group A showed an overall higher perception in all QoL scores at baseline and after 6-months ( p < 0.05). E2V/DNG treatment did not exert any significant effect on QoL perception in group A apart from an increase in the GH domain (general health). In group B we observed a significant improvement both in GH and in VT (vitality) scores. We found a significant reduction in 'lubrication' after 6 months both in group A and B ( p < 0.01) and a significant improvement in 'satisfaction' and 'pain' scores in group A and in 'desire', 'satisfaction' and 'total' score in group B ( p < 0.01). The E2V/DNG pill is associated with a significant improvement of GH and VT and with an improvement in FSF with no difference between age groups. 这是一项关于戊酸雌二醇/地诺孕素是否对年龄在25岁-45岁的102名女性生活质量(QOL)和性功能(FSF)有影响的观察性研究。39名女性小于35岁(A组),63名女性大于35岁或更大(B组)。在未用药和用药6个月后,患者接受意大利版的36个问卷调查和女性性功能指数问卷调查。未用药及用药6个月后(p<0.05),A组显示总体的生活质量评分更高。除了提高GH(一般健康状况)外,戊酸雌二醇/地诺孕素对A组生活质量没有任何明显影响。我们观察到B组GH和VT(体力)评分明显升高。我们发现6个月后A组和B组(p<0.01)'性润滑'作用明显降低,A组'性满意度'和'性交疼痛'评分明显升高;B组'性欲'、'性满意度'和'总'评分(p<0.01)明显升高。戊酸雌二醇/地诺孕素明显改善GH和VT,在不同年龄组中对性功能的改善没有显著差异。 [ABSTRACT FROM AUTHOR]