Thermal-Induced Dimerization Cyclization of Ethyl N-(Styrylcarbamoyl)acetates: Formation of 4-Hydroxy-2(1 H )-pyridone-3- carboxamide Derivatives.
- Resource Type
- Article
- Authors
- Zhao, Sheng-Yin; Liu, Bao-Shuo; Huang, Jing; Cheng, Shao-Hua; Deng, Yun-xia; Shao, Zhi-Yu
- Source
- Synthetic Communications. Jul2014, Vol. 44 Issue 14, p2066-2075. 10p.
- Subject
- *THERMAL analysis
*DIMERIZATION
*RING formation (Chemistry)
*ACETATES
*HYDROXY acids
*CARBOXAMIDES
*CHEMICAL derivatives
- Language
- ISSN
- 0039-7911
Thermal-induced dimerization cyclization of ethyl N-(styrylcarbamoyl)acetate derivatives has been investigated, leading to 4-hydroxy-2(1H)-pyridone-3-carboxamide derivatives with good yields in diphenyl ether on 200–210 °C. Ethyl N-(styrylcarbamoyl)acetate derivatives readily provided the intermolecular cyclization products 4-hydroxy-2(1H)-pyridone-3-carboxylates on reflux in xylene. In addition, several related 3-acetyl-4-hydroxy-5-phenylpyridin-2(1H)-ones have been prepared. It provided an efficient preparation of 4-hydroxy-2(1H)-pyridone-3-carboxamide derivatives. [ABSTRACT FROM AUTHOR]