Scalable micro-cavity bilayer lipid membrane arrays for parallel ion channel recording.
- Resource Type
- Article
- Authors
- Saha, Shimul Chandra; Thei, Federico; de Planque, Maurits R.R.; Morgan, Hywel
- Source
- Sensors & Actuators B: Chemical. Aug2014, Vol. 199, p76-82. 7p.
- Subject
- *BILAYER lipid membranes
*ION channels
*MICROCAVITY lasers
*SOLID lubricants
*HEMOLYSIS & hemolysins
*ELECTRODES
- Language
- ISSN
- 0925-4005
Highlights: [•] A compact, scaleable and high-throughput bilayer platform. [•] Each chip supports four bilayers independently and recorded by custom made ASIC. [•] Electrode and bilayer aperture size are defined individually using dry film resist. [•] Bilayers are stable up to 10 days and electrode can support recording for weeks. [•] The system performance is validated by recording gramicidin A and α-hemolysin. [ABSTRACT FROM AUTHOR]