The section sensitivity profile (SSP) was well understood in the case of single-row-detector spiral CT. With the introduction of multi-row-detector spiral CT and the transition into cone-beam spiral CT, a revisit to the SSP issue becomes necessary. In this paper, the SSP of multi-row-detector spiral CT is formulated for the half-scan interpolation method at any transverse position. Based on the SSP formula, numerical simulation is performed to quantify the characteristics of the SSP with the number of detector rows up to 40. It is shown that the SSP varies as a function of the pitch and the number of detector rows. Given an appropriate selection of the pitch and the number of detector rows, the SSP does not change very much over the field of view in terms of the mean, the slice thickness, and the skewness of the SSP. Although in general applications the SSP at the gantry iso-center can be used as the representative of the SSP family, for more accurate analyses the spatial variation of the SSP must be taken into account. [ABSTRACT FROM AUTHOR]