Genotoxic evaluation of five Angiotesin II receptor blockers: In vivo and in vitro micronucleus assay.
- Resource Type
- Article
- Authors
- Huerta, Iratxe; Barasoain, Maitane; Télez, Mercedes; Longa, Mikel; Muga, Javier; Barrenetxea, Gorka; Ortiz-Lastra, Eduardo; González, Javier; Criado, Begoña; Arrieta, Isabel
- Source
- Mutation Research - Genetic Toxicology & Environmental Mutagenesis. Jun2014, Vol. 767, p1-7. 7p.
- Subject
- *GENETIC toxicology
*ANGIOTENSIN-receptor blockers
*NUCLEOLUS
*BIOLOGICAL assay
*CELL-mediated cytotoxicity
*IN vitro studies
- Language
- ISSN
- 1383-5718
Highlights: [ • ] The genotoxic effects of five angiotensin II receptor blockers were investigated. [ • ] The genotoxic effect (MN and BNMN frequencies) is higher in vitro. [ • ] The cytotoxicity assay reveals a significant decrease of NDI in vitro. [•] FISH analysis suggests a non aneugenic potential for ARBs in vivo. [•] No correlation between MN and BNMN frequencies and duration of treatment was found. [ABSTRACT FROM AUTHOR]