Tremella Polysaccharides attenuated sepsis through inhibiting abnormal CD4+CD25high regulatory T cells in mice.
- Resource Type
- Article
- Authors
- Shi, Zhen-wei; Liu, Yi; Xu, Yan; Hong, Yu-rong; Liu, Qi; Li, Xiao-lu; Wang, Zhi-gang
- Source
- Cellular Immunology. Mar2014, Vol. 288 Issue 1/2, p60-65. 6p.
- Subject
- *TREMELLA
*POLYSACCHARIDES
*SEPSIS
*INHIBITION (Chemistry)
*CELL differentiation
*LABORATORY mice
- Language
- ISSN
- 0008-8749
Highlights: [•] The changes of IL-10 secreted by CD4+CD25high Tregs induced by Tremella Polysaccharides (TPS) in model mice. [•] The influences of TPS on the activation and differentiation of CD4+T cell collected from sepsis mice. [•] TPS promoted CD4+T cells proliferation and oriented CD4+T cells to Th1 differentiation. [•] TPS could improve the lethality of mice suffered from burn plus P. aeruginosa infection. [ABSTRACT FROM AUTHOR]