rs2243268 and rs2243274 of Interleukin-4 (IL-4) gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children.
- Resource Type
- Article
- Authors
- Qi, Hui; Sun, Lin; Jin, Ya-Qiong; Shen, Chen; Chu, Ping; Wang, Sheng-Feng; Yin, Qing-Qin; Qi, Zhan; Xu, Fang; Jiao, Wei-Wei; Wu, Xi-Rong; Tian, Jian-Ling; Xiao, Jing; Shen, A-Dong
- Source
- Infection, Genetics & Evolution. Apr2014, Vol. 23, p121-128. 8p.
- Subject
- *INTERLEUKIN-4
*TUBERCULOSIS in children
*INTERLEUKIN-10
*DISEASE susceptibility
*TUBERCULOSIS treatment
- Language
- ISSN
- 1567-1348
Highlights: [•] We choose Chinese Han children for investigating the susceptibility to tuberculosis. [•] Rs2243268-A and rs2243274-G are associated with reduced risk for EPTB and severe TB. [•] The stimulated levels of IL-10 and IL-17A were influenced by genotypes of rs2243268. [ABSTRACT FROM AUTHOR]