Synthetic Studies toward Amphidinolide H1: Segment C14-C26.
- Resource Type
- Article
- Authors
- Deng, Lisheng; Ma, Zhixiong; Zhang, Yazhu; Zhao, Gang
- Source
- Synlett. 2007, Issue 1, p0087-0090. 4p.
- Subject
- *MACROLIDE antibiotics
*ALDOLS
*WITTIG reaction
*HYDROXYLATION
*DINOFLAGELLATES
- Language
- ISSN
- 0936-5214
Stereoselective synthesis of the C14-C26 moiety of �amphidinolide H1 is described. The key features of the approach �include the convergent fragment assembly with a highly diastereoselective aldol reaction to establish the C18 stereochemistry and �using commercially available chiral pool. [ABSTRACT FROM AUTHOR]