Effects of thapsigargin in normal and pretreated with ryanodine guinea pig cardiomyocytes.
- Resource Type
- Article
- Authors
- Lewartowski, Bohdan; Rozycka, Monika
- Source
- American Journal of Physiology. May94, Vol. 266 Issue 5, pH1829. 11p. 2 Charts, 19 Graphs.
- Subject
- *CALCIUM antagonists
*HEART cells
*MYOCARDIUM
*PHYSIOLOGY
*CYTOCHEMISTRY
- Language
- ISSN
- 0002-9513
Investigates the effects of thapsigargin (TG), a calcium blocker, in isolated myocytes of guinea pig ventricular myocardium. Application of TG to the cells pretreated with ryanodine; Effects of TG on cytosolic free calcium concentration, cellular action potentials and Ca2+ current of single myocytes; Effect of TG on cells loaded with indo 1 acetoxymethyl ester.