A novel nanoparticle containing MOG peptide with BTLA induces T cell tolerance and prevents multiple sclerosis.
- Resource Type
- Article
- Authors
- Yuan, Bangqing; Zhao, Lin; Fu, Fenlan; Liu, Yongping; Lin, Chuangan; Wu, Xianqun; Shen, Hanchao; Yang, Zhao
- Source
- Molecular Immunology. Feb2014, Vol. 57 Issue 2, p93-99. 7p.
- Subject
- *NANOMEDICINE
*T cells
*MULTIPLE sclerosis
*LABORATORY mice
*CD4 antigen
*IMMUNIZATION
*IMMUNE response
- Language
- ISSN
- 0161-5890
Highlights: [•] We utilized a novel nanoparticle transduced DCs to immunized EAE mice. [•] We found that modified DCs could induce specific CD4+ T-cells tolerance. [•] Our results provided a promising therapeutic means to negatively manipulate immune response for autoimmune diseases. [ABSTRACT FROM AUTHOR]