Synthesis, Crystal Structure, DNA Binding, Antibacterial, and Cytotoxic Activities of Two Chiral Copper(II) Complexes.
- Resource Type
- Article
- Authors
- Fei, Bao‐Li; Li, Wen; Xu, Wu‐Shuang; Long, Jian‐Ying; Liu, Qing‐Bo; Sun, Wei‐Yin; Anson, Christopher E.; Powell, Annie K.
- Source
- European Journal of Inorganic Chemistry. Dec2013, Vol. 2013 Issue 34, p5919-5927. 9p.
- Subject
- *CHIRALITY
*COPPER compounds
*PROTEIN binding
*SCHIFF base derivatives
*COPPER ions
- Language
- ISSN
- 1434-1948
Two chiral copper(II) complexes [Cu(L)2Cl]Cl ( 1) and [Cu(L)2Br]Br ( 2) {L = N-[(pyridin-2-ylmethylene)imino]dehydroabietylamine} have been synthesized and fully characterized. The coordination geometry of the CuII ions in 1 and 2 can be described as an intermediate between square-pyramidal and trigonal-bipyramidal. DNA binding studies suggest that the complexes interact with salmon-sperm DNA through intercalation, and 2 exhibits a higher binding affinity. The new complexes were screened for their antibacterial and cytotoxic ability. They have similar cytotoxic activity and they represent the first rosin-derivative-based simple Schiff base complexes with strong anticancer potential. [ABSTRACT FROM AUTHOR]