The early changes in behavior and the myelinated fibers of the white matter in the Tg2576 transgenic mouse model of Alzheimer's disease.
- Resource Type
- Article
- Authors
- Zhang, Lei; Lu, Wei; Chen, Lin; Qiu, Xuan; Li, Chen; Huang, Chun-xia; Gong, Xia; Min, Qi-cheng; Lu, Fang; Wan, Jing-yuan; Chao, Feng-lei; Tang, Yong
- Source
- Neuroscience Letters. Oct2013, Vol. 555, p112-117. 6p.
- Subject
- *BEHAVIORAL research
*WHITE matter (Nerve tissue)
*CENTRAL nervous system
*TRANSGENIC mice
*ALZHEIMER'S disease
- Language
- ISSN
- 0304-3940
Highlights: [•] The Aβ deposition in the white matter appeared before the change in spatial learning memory. [•] The axon change in the white matter might be one of the morphological causes of the behavioral deficits. [•] The early detection of the Aβ content in the white matter might help diagnose suspected AD. [•] Protecting the axons in the white matter might be an important method for delaying the progression of AD. [ABSTRACT FROM AUTHOR]