RNAi screening identifies GSK3β as a regulator of DRP1 and the neuroprotection of lithium chloride against elevated pressure involved in downregulation of DRP1.
- Resource Type
- Article
- Authors
- Wu, Ji-Hong; Zhang, Sheng-Hai; Gao, Feng-Juan; Lei, Yuan; Chen, Xin-Ya; Gao, Feng; Zhang, Shu-Jie; Sun, Xing-huai
- Source
- Neuroscience Letters. Oct2013, Vol. 554, p99-104. 6p.
- Subject
- *RNA interference
*GLYCOGEN synthase kinase-3
*DYNAMIN (Genetics)
*NEUROPROTECTIVE agents
*LITHIUM chloride
*GENETIC regulation
- Language
- ISSN
- 0304-3940
Highlights: [•] Identification of GSK3β as a novel regulator of DRP1 under hydrostatic pressure. [•] LiCl downregulated DRP1 expression under hydrostatic pressure or IOP elevation. [•] Neuroprotection of LiCl involved in the inhibition of mitochondrial fission. [•] GSK3β inhibition may provide beneficial clues for glaucoma therapy. [ABSTRACT FROM AUTHOR]