In the title compound, [Mn(C10H6O7)(C12H10N2)(H2O)2] n or [Mn(HOABDC)(bpe)(H2O)2] n [H3OABDC is 5-(carboxymethoxy)isophthalic acid and bpe is 1,2-bis(pyridin-4-yl)ethylene], each MnII cation is at the centre of a distorted octahedron formed by three carboxylate O atoms from three different HOABDC2− ligands, one pyridyl N atom from the terminal bpe ligand and two water molecules. The flexible oxyacetate group bound to a methylene C atom of the HOABDC2− ligand links the MnII centres into -Mn-O-C-O-Mn- chains, and the carboxylate group bound directly to the benzene ring extends the chains into two-dimensional layers which lie parallel to the (010) plane and present herringbone patterns. Intermolecular O-H...N and C-H...O hydrogen bonds connect the layers into a three-dimensional supramolecular structure. [ABSTRACT FROM AUTHOR]