One-pot synthesis and crystal structure of an unusual amidine derived from heterocyclic ketene aminal derivative.
- Resource Type
- Article
- Authors
- Yang, Penghui; Wang, Wenzhen; Duan, Yanshan; Qu, Chengtun; Zhang, Qunzheng
- Source
- Heterocyclic Communications. Jun2013, Vol. 19 Issue 3, p167-169. 3p.
- Subject
- *AMIDINES
*KETENE derivatives
*ACETONE
*PROLINE
*SINGLE crystals
- Language
- ISSN
- 0793-0283
One-pot reaction of Meldrum's acid ( 1) and heterocyclic ketene aminal (HKA, 2) in acetone affords an unusual amidine HKA derivative 4. The reaction catalysts were optimized and it was found that l-proline is the best catalyst for the one-pot reaction. The mechanism is discussed. The structure of compound 4 was determined by single crystal X-ray analysis. [ABSTRACT FROM AUTHOR]