Vaccination protects rats from methamphetamine-induced impairment of behavioral responding for food.
- Resource Type
- Article
- Authors
- Rüedi-Bettschen, Daniela; Wood, Sherri L.; Gunnell, Melinda G.; West, C. Michael; Pidaparthi, Rama R.; Carroll, F. Ivy; Blough, Bruce E.; Owens, S. Michael
- Source
- Vaccine. Sep2013, Vol. 31 Issue 41, p4596-4602. 7p.
- Subject
- *ANIMAL vaccination
*METHAMPHETAMINE abuse
*DRUG side effects
*LABORATORY rats
*IMMUNIZATION
*MEDICATION safety
*THERAPEUTICS
- Language
- ISSN
- 0264-410X
Highlights: [•] A vaccine (ICKLH-SMO9) for treatment of methamphetamine abuse was tested in rats. [•] Repeated immunization with ICKLH-SMO9 caused no apparent adverse effect. [•] ICKLH-SMO9 protects from methamphetamine-induced reductions in responding for food. [•] METH serum concentrations substantially increased due to anti-METH antibody binding. [•] These studies suggest the vaccine is effective and safe. [ABSTRACT FROM AUTHOR]