Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks.
- Resource Type
- Article
- Authors
- Zhang, Xiuli; Lv, Lingna; Chen, Qian; Yuan, Fenghua; Zhang, Ting; Yang, Yeran; Zhang, Hui; Wang, Yun; Jia, Yan; Qian, Liangyue; Chen, Benjamin; Zhang, Yanbin; Friedberg, Errol C.; Tang, Tie-Shan; Guo, Caixia
- Source
- DNA Repair. May2013, Vol. 12 Issue 5, p377-388. 12p.
- Subject
- *DNA polymerases
*DNA damage
*DNA repair
*C-terminal binding proteins
*PROLIFERATING cell nuclear antigen
*BIOCHEMISTRY
- Language
- ISSN
- 1568-7864
Highlights: [•] Polκ accumulates at laser-induced sites of damage via its C-terminus. [•] The MSH2- and Rad18-dependent monoubiquitinated PCNA is required for efficient Polκ accumulation. [•] Polκ-deficient MEFs are sensitive to H2O2 treatment and have a defect in single-strand break repair and double strand break repair. [ABSTRACT FROM AUTHOR]