GOLPH3 regulates the migration and invasion of glioma cells though RhoA.
- Resource Type
- Article
- Authors
- Zhou, Xiuping; Zhan, Wenjian; Bian, Wenbin; Hua, Lei; Shi, Qiong; Xie, Shao; Yang, Dongxu; Li, Yanwei; Zhang, Xu; Liu, Guanzheng; Yu, Rutong
- Source
- Biochemical & Biophysical Research Communications. Apr2013, Vol. 433 Issue 3, p338-344. 7p.
- Subject
- *PHOSPHOPROTEINS
*CELL migration
*GLIOMAS
*BIOLOGICAL invasions
*CELL motility
*CYTOSKELETON
- Language
- ISSN
- 0006-291X
Highlights: [•] GOLPH3 downregulation induced a distinct reduction of glioma cell motility. [•] GOLPH3 downregulation inhibited the expression of RhoA. [•] GOLPH3 downregulation suppressed cytoskeleton reorganization. [•] RhoA overexpression rescued GOLPH3 knockdowning induced cell migration. [ABSTRACT FROM AUTHOR]