A single nucleotide polymorphism in the 5' untranslated region of RAD51 and ovarian cancer risk in Polish women.
- Resource Type
- Article
- Authors
- Romanowicz-Makowska, H.; Smolarz, B.; Samulak, D.; Michalska, M.; Lewy, J.; Burzyński, M.; Kokotaszwili, G.
- Source
- European Journal of Gynaecological Oncology. 2012, Vol. 33 Issue 4, p406-410. 5p.
- Subject
- *OVARIAN cancer
*RAD51 recombinase
*DNA repair
*GENETIC polymorphisms
*POLYMERASE chain reaction
*CANCER risk factors
- Language
- ISSN
- 0392-2936
The article presents a study which examined the influence of DNA repair genes RAD51-135G>C and 172>T in the risks for ovarian cancer. The study performed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) on RAD51 (135>C and 172G>T) of ovarian cancer patients and healthy controls. Result suggested the association of 135G>C polymorphism in ovarian cancer risk, however no association was found in 172G>T polymorphism.