This article presents both theoretical and experimental determination of the hydrodynamics of drying air in an industrial countercurrent spray dryer. Air velocity measurements were performed in selected areas of the tower to determine the flow pattern in the dryer and to collect data to validate the computational fluid dynamics (CFD) modeling and verify the results. For no-swirl operation mode, 3D CFD calculations showed high instability of the air flow in the dryer. A bent, pillow-shaped flow above the drying air inlet, which promotes deposition of particles in this area of the wall, was detected. CFD calculations also proved that when drying air was introduced to the tower tangentially; from 20° to 30° in relation to the initial air flow configuration in the spray-drying tower, the air flow was stabilized and air velocity near the wall increased, which might reduce wall deposition of particles. Comparison of experimental and theoretical results showed that the CFD model of countercurrent spray-drying process developed in this study can be used for a reliable estimation of tower performance. [ABSTRACT FROM AUTHOR]