Designed to penetrate: Time-resolved interaction of single antibiotic molecules with bacterial pores.
- Resource Type
- Article
- Authors
- Nestorovich, Ekaterina M.; Danelon, Christophe; Winterhalter, Mathias; Bezrukov, Sergey M.
- Source
- Proceedings of the National Academy of Sciences of the United States of America. 7/23/2002, Vol. 99 Issue 15, p9789. 6p. 3 Diagrams, 6 Graphs.
- Subject
- *BACTERIA
*ANTIBIOTICS
- Language
- ISSN
- 0027-8424
Examines the factors contributing to the intrinsic resistance of bacteria to antibiotics. Interaction of ampicillin molecules, penicillins and cephalosporins with the residues of the constriction zone of the OmpF channel; Evolution of antibiotics into channel-specific; Use of molecular modeling.