A method to estimate treatment efficacy among latent subgroups of a randomized clinical trial.
- Resource Type
- Article
- Authors
- Altstein, Lily L.; Li, Gang; Elashoff, Robert M.
- Source
- Statistics in Medicine. 3/30/2011, Vol. 30 Issue 7, p709-717. 8p.
- Subject
- *SURVIVAL analysis (Biometry)
*MELANOMA
*MEDICAL research
*STATISTICAL correlation
*CLINICAL trials
- Language
- ISSN
- 0277-6715
The article discusses research describing a general framework to estimate a biological treatment effect on the latent subgroup of interest when the survival outcome is right-censored. It notes that the framework is based on the application of instrumental variables approaches to all-or-none non-compliance and derived to estimate model parameters. It states that an analysis of a seminal melanoma trial that proposed a new standard of care for the disease illustrates the research.