Regioselective synthesis of 1,3,5- and 1,3,4,5-substituted pyrazoles via acylation of N-Boc-N-substituted hydrazones
- Resource Type
- Article
- Authors
- Tinarelli, Alessandro; Righi, Paolo; Rosini, Goffredo; Andreotti, Daniele; Profeta, Roberto; Spada, Simone
- Source
- Tetrahedron. Jan2011, Vol. 67 Issue 3, p612-617. 6p.
- Subject
- *PYRAZOLES
*ORGANIC synthesis
*ACYLATION
*HYDRAZONES
*CHEMICAL reactions
*ORGANIC chemistry
- Language
- ISSN
- 0040-4020
Abstract: Acylation of N-Boc-N-methylhydrazones followed by TFA treatment affords regioselective access to substituted pyrazoles. Both regioisomers of 1-methyl-3,5-disubstituted-1H-pyrazoles can be selectively obtained. This procedure can also be employed for the regioselective preparation of fully substituted 1H-pyrazoles. [ABSTRACT FROM AUTHOR]