Salmonella typhimurium thy A mutants fail to grow intracellularly in vitro and are attenuated in mice.
- Resource Type
- Article
- Authors
- Kok, Menno; Buhlmann, Elisabeth; Pechere, Jean-Claude
- Source
- Microbiology (13500872). Mar2001, Vol. 147 Issue 3, p727-733. 7p. 2 Charts, 2 Graphs.
- Subject
- *SALMONELLA typhimurium
*MICROBIAL enzymes
- Language
- ISSN
- 1350-0872
Examines the behavior of Salmonella typhimurium thyA mutants, which lack the enzyme thymidylate synthase and are incapable of synthesizing DNA in the absence of precursors of thymidine monophosphate in the growth medium. Genetic defect in thyA mutants; Intracellular survival of Salmonella typhimurium thyA; Virulence of thyA mutants.