Angiotensin II Receptor Blockade Administered After Injury Improves Muscle Regeneration and Decreases Fibrosis in Normal Skeletal Muscle.
- Resource Type
- Article
- Authors
- Bedair, Hany S.; Karthikeyan, Tharun; Quintero, Andres; Li, Yong; Huard, Johnny,
- Source
- American Journal of Sports Medicine; Aug2008, Vol. 36 Issue 8, p1548-1554, 7p, 7 Color Photographs, 1 Chart, 2 Graphs
- Subject
- Angiotensin II
Fibrosis
Tissues
Muscles
Transforming growth factors
Regeneration (Biology)
Sports injuries
Laboratory mice
Histology
- Language
- ISSN
- 03635465
The article reports on therapeutic agents that suppresses fibrosis like angiotensin receptor blockers. These agents help in the regeneration of skeletal muscle after an injury. Systemic treatment with an angiotensin blocker for animals after an injury is believed to decrease cases of fibrosis and improve regeneration of muscles and healing through transforming growth factor-β1 blockade. Histological examinations on mice after treatment of angiotensin receptor blocker reveals an improvement in muscle regeneration and fibrous tissue reduction. The result shows that angiotensin II, angiotensin receptor blocker therapy helps in skeletal muscle regeneration and can be used not only for sports and military-related injuries but also diseases like muscular dystrophies.