This article presents an abstract of the research paper "Immunohistochemical Analysis of Selected Parameters of Tissues in the Immediate Surroundings of Tumours in Surgical Material of Gliomas and Metastases to the Central Nervous System," which was discussed in the 13th Conference of the Polish Association of Neuropathologist. The paper states that the spreading of the tumour in a tissue depends on many factors. In the glia setting, elements like anatomical structures of the white matter tracts, submeningeal spaces, cerebrospinal fluid and blood vessels gain more significance; they are connected with the extracellular matrix proteins.