Background: In women with recurrent disease who were conservatively treated for atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EEC), the reasons why conservative treatment was chosen persist and outcomes of performing a conservative re‐treatment are unclear, as pooled estimates on oncologic outcomes of such a re‐treatment are lacking. Objectives: To provide pooled estimates of oncologic outcomes of conservative re‐treatment in women with recurrent AEH or EC. Search Strategy: A systematic review and meta‐analysis was performed by searching six electronic databases from their inception to March 2022. Selection Criteria: Studies that allowed extraction of data about oncologic outcomes of conservative re‐treatment of women with recurrent AEH and EEC after a conservative treatment. Data Collection and Analysis: Pooled prevalence of complete response (CR), poor response (PR), and recurrence after conservative re‐treatment was calculated. Main Results: Fifteen studies (12 retrospective and 3 prospective) with 492 women (42.1% AEH and 57.9% EEC) were included in the systematic review, and 10 studies (8 retrospective and 2 prospective) were suitable for the meta‐analysis. Pooled prevalence was 85.3% (95% confidence interval [CI] 77.0%–91.0%) for CR, 14.7% (95% CI 9.0%–23.0%) for PR, and 40.4% (95% CI 15.5%–71.4%) for recurrence. Conclusions: Conservative re‐treatment in AEH or EC recurrent women has a high CR rate and acceptable recurrence rate that might allow it to be considered a safe and viable option, at least as a first round of conservative treatment. Women with an unsatisfied desire for motherhood or with high surgical risk might avoid hysterectomy and attempt childbearing or spare high‐risk surgery. Synopsis: Conservative re‐treatment in women with recurrent AEH or EC may be considered a viable option, at least as a first round of conservative treatment. [ABSTRACT FROM AUTHOR]