Exploring the Protective Effect of Total Flavonoids from Semen Cuscutae on Ovarian Germline Stem Cells Based on Notch Signaling Pathway.
- Resource Type
- Article
- Authors
- Li, Yuan; Du, Hanqian; Li, Jiashan; Li, Zehui; Guo, Li; Xu, Panyu; Xu, Ying; Lin, Na
- Source
- Stem Cell Reviews & Reports. Apr2024, Vol. 20 Issue 3, p852-854. 3p.
- Subject
- *NOTCH signaling pathway
*NOTCH genes
*STEM cells
*GERM cells
*SEMEN
*MOLECULAR biology
- Language
- ISSN
- 1550-8943
This article explores the protective effect of Total Flavonoids from Semen Cuscutae (TFSC) on ovarian germline stem cells (OGSCs) based on the Notch signaling pathway. The study challenges the belief that the number of primordial follicles in the ovaries remains constant and suggests that there is a natural replenishment of oocytes after birth. The researchers found that TFSC promotes the proliferation of OGSCs and enhances the expression of stem cell markers. Additionally, TFSC influences OGSCs through its effects on the Notch signaling pathway. These findings provide new targets for studying the effects of TFSC on female reproductive disorders. [Extracted from the article]