The article focuses on exploring lineage plasticity in adult stem cells, specifically hair follicle stem cells (HFSCs) in the skin, to understand the signaling pathways involved in their transition to a plastic state during tissue regeneration. It study identifies all-trans retinoic acid (atRA), a vitamin A metabolite, as a crucial regulator of HFSC lineage plasticity, affecting their physiological identity and contribution to distinct lineages required for hair follicle formation.