A meta-analysis published in the journal Human Reproduction Update provides evidence in favor of the effectiveness of endometrial scratching before in vitro fertilization (IVF). The analysis integrates data from 13 high-quality randomized controlled trials (RCTs) and demonstrates a modest but significant positive effect of the intervention. The study suggests that luteal phase, natural cycle scratching may be superior to other timing methods. The findings contradict previous studies that suggested a more favorable effect with increasing female age or after multiple failed transfers. While the limitations of individual studies cannot be overcome, the authors have made the most of the available evidence. The study challenges the prevailing belief that endometrial scratching is ineffective and highlights the need for further research to understand the underlying mechanisms. [Extracted from the article]