This article discusses the role of BCL11B, a transcriptional regulator of T cells, in T-cell acute lymphoblastic leukemia (T-ALL). The study identifies XRCC5 as a binding protein of BCL11B and suggests that XRCC5 may regulate BCL11B expression to inhibit apoptosis in T-ALL cells. Additionally, the study identifies C11ORF21 as a target gene of BCL11B that may also contribute to the pathogenesis of T-ALL. The findings suggest that the XRCC5/BCL11B/C11ORF21 signaling pathway could be a potential target for the treatment of T-ALL. [Extracted from the article]