The article discusses a study conducted by the Canadian taTME collaboration (CaTaCO) on the outcomes of transanal total mesorectal excision (taTME) for abdominoperineal resection (APR) in rectal cancer patients. The authors respond to a comment made by Drs May and Bethune, who criticized the study's methodology. The authors argue that their objective was to compare a specific surgical approach for APR and low anterior resection (LAR), and they believe that the taTME approach may not be ideal for APR surgery. They emphasize the need for further research and caution against declaring any approach as the best for APR without comparing all known treatments. [Extracted from the article]