A recent study published in Cell Biology International explores the potential of targeting mitochondrial RNA modifications as a therapeutic strategy to combat metastasis in late-stage cancers. The study focuses on the role of NSUN3, a mitochondrial RNA methyltransferase, and its involvement in the activation of tumor cell invasion and dissemination. The researchers found that inhibiting NSUN3-dependent RNA modifications can decrease the progression of lymph node metastasis without affecting primary tumor growth. Additionally, the study highlights the potential of antibiotics that inhibit mitochondrial translation as a treatment strategy to prevent cancer metastasis. Overall, this research provides valuable insights into the role of mitochondrial RNA modifications in tumor metastasis and suggests potential therapeutic targets for late-stage cancers. [Extracted from the article]