This article discusses a condition called Asplenia-related Post-antimalarial Inflammation and Hemolysis (APIH) that can occur in patients with a lack of spleen function. The condition is characterized by slow parasite clearance, persistent or recurrent fever, hemolytic anemia, and inflammation. The article presents two case studies of patients with APIH and describes the symptoms and treatment outcomes. The authors suggest that APIH should be considered as a potential cause of treatment failure in malaria patients, especially those with impaired spleen function. [Extracted from the article]