This study investigates how cultural differences, gender role priming, partner's sexual preferences, and women's experienced sexual pleasure influence women's likelihood of consenting to their least favorite sexual practices, including oral sex, anal sex, and having sex when not in the mood. We compared predictors of sexual consent of cisgender heterosexual Chinese and American women as well as how traditional versus egalitarian gender role priming influenced sexual consent. 412 participants completed an online survey. The results revealed that women were more likely to consent to than enjoy the sexual practices examined. Women's experienced sexual pleasure and their partner's sexual preferences were positively correlated with women's sexual consent. More specifically, women's sexual consent was more influenced by partner's sexual preferences, and less influenced by experienced sexual pleasure when exposed to traditional marriage priming compared to egalitarian marriage priming. And Chinese women's sexual consent was more influenced by partner's sexual preferences and less influenced by experienced sexual pleasure compared to American women. Traditional gender role priming made women more likely to have sex when not in the mood compared to egalitarian gender role priming, and made Chinese women more likely and American women less likely to consent to anal sex, respectively, compared to egalitarian gender role priming. Overall, cultural and situational differences in gender role expectations significantly influenced the determinants of women's consent to their least favorite sexual practices, despite cross-cultural consistencies. [ABSTRACT FROM AUTHOR]