Synthesis of Perfluoro Alkyl/Alkenyl Aryl Sulfide: C−S Coupling Reaction Using Hexafluoropropylene Dimer (HFPD) as a Building Block.
- Resource Type
- Article
- Authors
- An, Yu; Zeng, Ji‐Jun; Tang, Xiao‐Bo; Zhao, Bo; Han, Sheng; Yang, Zhi‐Qiang; Zhang, Wei; Lu, Jian
- Source
- European Journal of Organic Chemistry. 1/2/2024, Vol. 27 Issue 1, p1-7. 7p.
- Subject
- *SULFIDES
*FLUOROALKYL compounds
*THIOPHENOL
*ALKENYL group
- Language
- ISSN
- 1434-193X
Efficient approaches to perfluoroalkyl/alkenyl aryl sulfides were accomplished by a C−S coupling reaction under mild conditions. Hexafluoropropylene dimer was employed as a versatile building block for the perfluoroalkylation and perfluoroalkenylation of thiophenol. The application of the synthetic strategy was demonstrated by the high‐yield transformation of a broad range of aryl derivatives. A plausible mechanistic explanation was proposed to elaborate the differences between the two reaction pathways. The methodology provides straightforward and convenient access to aryl sulfides constituting C6 perfluoroalkyl and perfluoroalkenyl substituents. [ABSTRACT FROM AUTHOR]