The study analysed prevalence of lower limb injuries and associated risk factors in Kazakhstan from 2012 to 2019. The information about lower extremity injuries (S70-S79, S80-S89, S90-S99 types) was obtained from the Republican Centre for Electronic Health. The gender ratio, age-period-cohort (APC), prevalence, and incidence of lower limb injury were calculated and analysed. Analysis showed an increase in the frequency of injuries to the lower limbs for the studied period. The observed trend was profound among the population over 55 years old. According to the APC analysis, children of both sexes had a tendency to lower limb injuries (with a peak of 10–15 years old). We found an association between age and the risk of lower extremity injuries. There is a sharp increase in lower extremity injuries rate at the age of 85 in both sexes. Modeling the cohort effects demonstrated the tendency of the risk for both sexes (more pronounced in the female population). We observed an increase in the number of injuries for the period studied with a peak in 2017–2018. [ABSTRACT FROM AUTHOR]