Stat5a sobers up inTOXicated T cells.
- Resource Type
- Article
- Authors
- Donhauser, Lara V.; Zehn, Dietmar
- Source
- Immunity (10747613). Dec2023, Vol. 56 Issue 12, p2670-2672. 3p.
- Subject
- *T cells
*T-cell exhaustion
*STAT proteins
*ANTINEOPLASTIC agents
- Language
- ISSN
- 1074-7613
Exhausted T cells are largely hampered by epigenetically enforced mechanisms that limit their effector potential. In this issue of Immunity , Beltra et al. found that Stat5 can alter these epigenetic profiles when T cells transition from the Tpex precursor stage into differentiated cells. At this stage, enforced Stat5 expression increases the number of intermediate exhausted T cells and induces durable effector cells with superior anti-tumor activity. [ABSTRACT FROM AUTHOR]