The attempts to recreate the facial appearances of mummies fascinate forensic anthropologists, archeologists, and the general public. Traditional manual facial approximation is commonly used in forensic anthropology and archeology. However, due to the lack of confident anatomical knowledge, practitioners’ subjective interpretation and imagination may potentially compromise the accuracy of approximation results. The aim of this study was to develop a computerized method to generate a probable face of a mummified skull (98QZIM139K) excavated from the Zaghunluq cemetery in Xinjiang, China. A multi-slice computed tomography scanner was used to obtain digital models of the skull and mummified facial soft tissues. Due to the insufficient evidence of actual soft tissues, the average facial soft tissue thickness depths (FSTDs) of modern humans were assigned to the exterior surface of the mummified skull to generate the facial profile. A facial statistical shape model was then used to improve the approximation by filling in missing regions and adding facial features. Additionally, two different probable faces of the same mummified skull were recreated by utilizing various FSTDs representing thin and obese status. The results show that the approximated face exhibits prominent supraorbital ridges, a high nose, and a prominent anterior edge of the mandible. This is the first case study of generating the facial appearance of a mummified skull in the Zaghunluq cemetery, which aids anthropologists and archeologists in examining the morphological differences between the mummy and modern human faces and quantifying the extent of soft tissue mummification. [ABSTRACT FROM AUTHOR]