Apo10 and TKTL1 in blood macrophages as biomarkers for differentiating lung cancer from benign lung lesions: a comparative study with conventional biomarkers.
- Resource Type
- Article
- Authors
- Xie, Chuanbo; Wang, Shuqing; Guo, Chi; Liu, Yuying; Zeng, Musheng
- Source
- Cellular Oncology (2211-3428). Dec2023, Vol. 46 Issue 6, p1725-1729. 5p.
- Subject
- *LUNG diseases
*LUNG cancer
*MACROPHAGES
*PULMONARY nodules
*EARLY detection of cancer
*LUNGS
- Language
- ISSN
- 2211-3428
The detection of biomarkers in blood macrophages is a new non-invasive cancer screening method, but its performance in early stage lung cancer screening remains undetermined. We evaluated the Apo10 and TKTL1 levels in blood macrophages of 156 early-stage lung cancer patients and 153 controls. APT (combination of Apo10 and TKTL1) level was significantly higher in the lung cancer group than that in the control group (P < 0.001). AUROC analysis showed that APT has high diagnostic value in differentiating early-stage lung cancer (AUC = 0.9132) and can be considered a biomarker for screening lung cancer patients from individuals with lung nodules. [ABSTRACT FROM AUTHOR]