Effective and safe acute-pain management practices are imperative for patients undergoing gynecologic surgery. Well-managed perioperative pain is associated with fewer postoperative complications, decreased hospital lengths of stay, lower readmission rates, better functional capacity, and improved health-related quality of life. This article reviews the available analgesic modalities used to provide high-quality acute pain control for patients undergoing gynecologic surgery. These modalities include topical agents, wound and intraperitoneal infusions, regional anesthetics, neuraxial blocks, peripheral nerve stimulation, and opioid and nonopioid analgesics. This article focuses on when each technique can be practically integrated into clinical practice, based on a thorough review of the current evidence. (J GYNECOL SURG 39:271) [ABSTRACT FROM AUTHOR]