Identification of 3′‐terminal 2′‐O‐methylated miRNA in plasma as a novel diagnostic biomarker of NSCLC.
- Resource Type
- Article
- Authors
- Guo, Xu; Guo, Hongyuan; Lu, Kuan‐Chen; Yan, Xin; Chen, Jiehao; Wei, Yanting; Han, Jiayi; Sun, Wu; Hu, Huanhuan; Su, Yuanyuan; Shen, Lingyan; Zhang, Yujing; Yin, Kai; Zhang, Chen‐Yu; Fu, Zheng
- Source
- Clinical & Translational Medicine. Nov2023, Vol. 13 Issue 11, p1-6. 6p.
- Subject
- *NON-small-cell lung carcinoma
*NON-coding RNA
*MICRORNA
- Language
- ISSN
- 2001-1326
This article discusses a study that explores the potential use of 3′t‐2′Ome miRNAs as diagnostic biomarkers for non-small cell lung cancer (NSCLC). The study analyzed 149 NSCLC patients and 146 control subjects to evaluate the diagnostic value of these miRNAs in plasma. The analysis found significant differences in underlying diseases between the cancer patients and control subjects, suggesting that 3′t‐2′Ome miRNAs may be useful in diagnosing NSCLC. The article also discusses the use of deep sequencing technology to study small RNA species and the identification of three methylated miRNAs that could serve as biomarkers for early detection of NSCLC. Further research is needed to explore the clinical value and functions of these methylated miRNAs. [Extracted from the article]