This article discusses a case study of a 48-year-old Italian woman with ichthyosis with confetti (IWC), a rare genetic skin disorder. The patient developed multiple melanomas, which is not a well-established association with this condition. The study identified a specific gene mutation in the patient and discussed potential mechanisms for the development of melanoma in individuals with IWC. The authors recommend careful monitoring of melanocytic lesions in patients with IWC. [Extracted from the article]