[128] The interaction of LSECs with Kupffer cells (KCs) is crucial to maintain liver health, as the depletion of KCs prior to acetaminophen insult aggravated DILI-mediated LSEC injury and enhanced the expression of cellular adhesion molecules in LSECs. Some promising options include exploring the immunomodulatory function of LSECs in the field of liver transplant, targeting LSEC luminal adhesion molecules in inflammatory liver diseases, and inhibiting shear-stress signaling pathways and subsequent proinflammatory molecule expression to ameliorate PH. These sinusoids are composed of liver sinusoidal endothelial cells (LSECs), which represent a subpopulation of endothelial cells in the liver with distinct features, such as lack of a basal membrane and the presence of fenestrae. Keywords: angiocrine signaling; liver sinusoidal endothelial cells; liver health; liver disease; therapeutics EN angiocrine signaling liver sinusoidal endothelial cells liver health liver disease therapeutics 245 257 13 11/03/23 20230801 NES 230801 Lay Summary Liver sinusoidal endothelial cells (LSECs) are key players in maintaining hepatic homeostasis. [Extracted from the article]