Eye is the most vital organ of body. The usual ophthalmic dosage forms are account for 90% of currently accessible ophthalmic formulations. The major trouble encountered is quick precornel drug loss. To improve oph thalmic drug bioavailability, there are considerable efforts directed towar ds newer drug delivery systems for ophthalmic administration. Newer research in ophthalmic drug delivery systems is directed towards an amalgamation of several drug delivery technologies, that includes to buid up systems whichis not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug. Conventional delivery systems often result in poor bioavailability and therapeutic response because high tear fluids turn over and dynamics causerapidelimination of the drug from the eyes. So, to overcome bioavai lability problems, ophthalmic in situ gels were developed. [ABSTRACT FROM AUTHOR]