Liver dysfunction during pregnancy can result in adverse pregnancy outcomes. (D) The cumulative abundance of liver-specific mRNA and miRNA genes was significantly increased in the HBV and ICP groups. (A) HBV genotypes determined by cfRNA in HBV-infected patients. These changes were distinct in patients with early- and late-diagnosed ICP, with the latter showing similar changes to HBV carriers, implicating different biological processes that drive the underlying pathophysiology of these subtypes of ICP. [Extracted from the article]