Glycated haemoglobin in the first year after diagnosis of type 1 diabetes is an independent risk factor for diabetic retinopathy: The IMDIAB 25 years follow-up study Effect of intensive diabetes therapy on the progression of diabetic retinopathy in patients with type 1 diabetes: 18 years of follow-up in the DCCT/EDIC. Keywords: HbA1c; metabolic memory; retinopathy; type 1 diabetes EN HbA1c metabolic memory retinopathy type 1 diabetes 3415 3419 5 10/05/23 20231101 NES 231101 BACKGROUND Intensive glycaemic control lowers the risk of microvascular complications.[1] This effect has been shown to persist for up to 18 years of follow-up.[[2], [4]] Whether the glycaemic control obtained during the first months after type 1 diabetes (T1D) onset has an impact on the future risk of chronic complications has not been clarified. Linear regression models were used to test the presence of any association between HbA1c at diabetes onset, mean-first-year HbA1c and HbA1c measured at last follow-up and to test baseline features associated with first-year HbA1c. [Extracted from the article]