Backgrond: We soght to examine whether electrical impedance spectroscopy (EIS), a diagnostic tool approved by the US Food and Drg Administration for the evalation of pigmented skin lesions (PSLs), is beneficial to primary care providers (PCPs) by comparing the accracy of PCPs’ management decisions for PSLs based on visal examination alone with those based on concrrent visal and EIS evalation. Methods: Physicians and nrse practitioners (NPs) participated in an anonymos online srvey in which they viewed clinical images of PSLs and were asked to make 2 clinical decisions before and after being provided an EIS score that indicated the likelihood that the lesion was a melanoma. They were asked (1) if they wold biopsy the lesion/refer the patient ot and (2) what they expected the pathology reslts wold show. Reslts: Forty-for physicians and 17 NPs participated, making clinical decisions for 1354 presented lesions. Overall, with the addition of EIS to visal inspection of clinical images, the sensitivity of biopsy/referral decisions for melanomas and severely dysplastic nevi (SDN) increased from 69.2% to 90.0% (P < .001), while specificity increased from 44.0% to 72.6% (P < .001). Physicians and NPs, regardless of years of experience, each saw significant improvements in sensitivity, specificity, and diagnostic accracy with the addition of EIS scores. Conclsions: The incorporation of EIS data into clinical decision-making by PCPs significantly increased the sensitivity and specificity of biopsy/referral decisions for melanomas and SDN and overall diagnostic accracy compared with visal inspection alone. The reslts of this stdy sggest that diagnostic accracy for PSLs by PCPs may be improved with adjnctive se of EIS with visal inspection. [ABSTRACT FROM AUTHOR]